Kenali Ubat Anda - Chlorpheniramine
What is chlorpheniramine?
Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Chlorpheniramine is used to treat sneezing, itching, watery eyes, and runny nose caused by allergies or the common cold.
Chlorpheniramine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about chlorpheniramine?
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not take chlorpheniramine if you are allergic to it. Ask a doctor or pharmacist before taking chlorpheniramine if you have glaucoma, a stomach ulcer, severe constipation, kidney disease, urination problems, an enlarged prostate, or a thyroid disorder.Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Chlorpheniramine is contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine.
Chlorpheniramine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine.
What should I discuss with my healthcare provider before taking chlorpheniramine?
Do not take this medication if you are allergic to chlorpheniramine. Do not use chlorpheniramine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:- glaucoma;
- a stomach ulcer;
- severe constipation;
- kidney disease;
- urination problems or an enlarged prostate; or
- a thyroid disorder.
How should I take chlorpheniramine?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.Take this medication with a full glass of water. Take chlorpheniramine with food or milk if it upsets your stomach. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.
Store at room temperature away from moisture and heat.
See also: Chlorpheniramine dosage (in more detail)
What happens if I miss a dose?
Since cold or allergy medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).What should I avoid while taking chlorpheniramine?
Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Chlorpheniramine is contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine. Avoid becoming overheated or dehydrated during exercise and in hot weather. Chlorpheniramine can decrease perspiration and you may be more prone to heat stroke.This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine.
Chlorpheniramine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop taking chlorpheniramine and call your doctor at once if you have a serious side effect such as:- urinating less than usual or not at all;
- confusion, extreme drowsiness;
- severe dizziness, anxiety, restless feeling, nervousness; or
- weak or shallow breathing.
- mild dizziness, drowsiness;
- blurred vision;
- dry mouth;
- nausea, stomach pain, constipation;
- problems with memory or concentration; or
- feeling restless or excited (especially in children).
Chlorpheniramine Dosing Information
Usual Adult Dose for Allergic Rhinitis:Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.
Usual Adult Dose for Cold Symptoms:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.
Usual Adult Dose for Urticaria:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.
Usual Adult Dose for Allergic Reaction:
Injectable solution:
Allergic reactions to blood or plasma infusions: 10 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.
Anaphylaxis: 10 to 20 mg intravenous injection as a single dose.
Uncomplicated Allergic Conditions: 5 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.
Maximum dose by injection is 40 mg/day.
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed.
Maximum dose 32 mg/day.
Usual Pediatric Dose for Allergic Rhinitis:
3 months to 5 months:
Sustained-release syrup: 0.5 mg orally every 12 hours.
6 months to 8 months:
Sustained-release syrup: 1 mg orally every 12 hours.
9 months to 18 months:
Sustained-release syrup: 1 to 1.5 mg orally every 12 hours.
18 months to 6 years:
Sustained-release syrup: 2 mg orally every 12 hours.
2 to 5 years:
Tablets or syrup: 1 mg every 4 to 6 hours.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.
Maximum dose 6 mg/day.
6 to 11 years:
Tablets or syrup: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg orally at bedtime or during the day as indicated.
Maximum dose 16 mg/day.
12 years or older:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.
Usual Pediatric Dose for Cold Symptoms:
3 months to 5 months:
Sustained-release syrup: 0.5 mg orally every 12 hours.
6 months to 8 months:
Sustained-release syrup: 1 mg orally every 12 hours.
9 months to 18 months:
Sustained-release syrup: 1 to 1.5 mg orally every 12 hours.
18 months to 6 years:
Sustained-release syrup: 2 mg orally every 12 hours.
2 to 5 years:
Tablets or syrup: 1 mg every 4 to 6 hours.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.
Maximum dose 6 mg/day.
6 to 11 years:
Tablets or syrup: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg orally at bedtime or during the day as indicated.
Maximum dose 16 mg/day.
12 years or older:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.
Usual Pediatric Dose for Urticaria:
3 months to 5 months:
Sustained-release syrup: 0.5 mg orally every 12 hours.
6 months to 8 months:
Sustained-release syrup: 1 mg orally every 12 hours.
9 months to 18 months:
Sustained-release syrup: 1 to 1.5 mg orally every 12 hours.
18 months to 6 years:
Sustained-release syrup: 2 mg orally every 12 hours.
2 to 5 years:
Tablets or syrup: 1 mg every 4 to 6 hours.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.
Maximum dose 6 mg/day.
6 to 11 years:
Tablets or syrup: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg orally at bedtime or during the day as indicated.
Maximum dose 16 mg/day.
12 years or older:
Tablets or syrup: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.
Usual Pediatric Dose for Allergic Reaction:
Injectable solution:
2 years to 11 years: 0.35 mg/kg/day in divided doses every 4 to 6 hours as needed.
12 years or older:
Allergic reactions to blood or plasma infusions: 10 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.
Anaphylaxis: 10 to 20 mg intravenous injection as a single dose.
Uncomplicated Allergic Conditions: 5 to 20 mg by intravenous, intramuscular, or subcutaneous injection as a single dose.
Maximum dose by injection is 40 mg/day.
Tablets or syrup:
2 to 5 years: 1 mg every 4 to 6 hours.
Maximum dose 6 mg/day.
Sustained-release: 2 mg orally two times a day, not to exceed 8 mg in 24 hours.
6 to 11 years: 2 mg every 4 to 6 hours.
Sustained-release: 4 to 8 mg orally two times a day, not to exceed 16 mg in 24 hours or 8 mg at bedtime or during the day as indicated.
Maximum dose 16 mg/day.
12 years or older: 4 mg orally every 4 to 6 hours.
Sustained-release: 8 to 16 mg orally every 8 to 12 hours as needed or 16 mg orally once a day as needed
Maximum dose 32 mg/day.
What other drugs will affect chlorpheniramine?
Other cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by chlorpheniramine. Tell your doctor if you regularly use any of these medicines. Tell your doctor about all other medicines you use, especially:- glycopyrrolate (Robinul);
- mepenzolate (Cantil);
- probenecid (Benemid, Probalan);
- rifampin (Rifadin, Rifater, Rifamate, Rimactane);
- zidovudine (Retrovir, AZT);
- a diuretic (water pill);
- atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
- bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
- bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
- irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro-Banthine); or
- salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others;
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